Science

Fusion protein holds promise for treating pulmonary arterial hypertension

Fusion protein holds promise for treating pulmonary arterial hypertension

In a paper published in Science Translational Medicine, researchers illuminate the underlying biological pathways that may lead to vessel destruction in pulmonary arterial hypertension. Their results provide a biological explanation for why proteins called activins and growth and differentiation factors (GDFs) might contribute to pulmonary vascular disease, and provide an explanation of how the activin/GDF-blocking drug sotatercept, currently in clinical trials, may help treat patients with pulmonary arterial hypertension.

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