Science

Polycythaemia vera: Determination of individual DNA variants allows for more effective treatment

Polycythaemia vera: Determination of individual DNA variants allows for more effective treatment

Polycythaemia vera is a chronic malignant disease of the haematopoietic system and is treated with interferon-alpha-based drugs, in most cases with long-lasting success. However, in some cases this therapy is unsuccessful for reasons that are not yet understood. A research group led by Robert Kralovics from MedUni Vienna’s Department of Laboratory Medicine and from CeMM has now conducted genetic association studies, which show that patients with certain DNA variants commonly found in the population do not respond sufficiently to the treatment.

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